Jeffrey S. McLean | UW Microbiology

Jeffrey S. McLean

Professor

School of Dentistry, Department of Periodontics

Adjunct Professor

Department of Microbiology

206 616-1808

jsmclean@uw.edu

Office:

HSB Room D-552

https://www.jsmcleanlab.com/

About the Lab

The goal of our program has been to gain an understanding for the molecular basis of bacteria-bacteria as well as bacteria-host interactions and further develop innovative methodologies, tools and integrated “omic” based approaches with wet-lab cultivation work on oral communities to understand and ultimately translate this fundamental knowledge to the overall benefit of human health. Our team has extensive experience in combining multi-omic approaches such as temporal resolved metatranscriptomic analysis in parallel with metabolomics profiling to reveal the homeostatic mechanisms of oral microbial communities. We track oral community assembly and succession, capturing the expression dynamics of key disease related species in relation to host responses.

NCBI publications

Publications

Kerns KA, Bamashmous S, Hendrickson EL, Kotsakis GA, Leroux BG, Daubert DD, Roberts FA, Chen D, Trivedi HM, Darveau RP, McLean JS.
Localized microbially induced inflammation influences distant healthy tissues in the human oral cavity. Proc Natl Acad Sci U S A. 2023 Oct 10;120(41):e2306020120. doi: 10.1073/pnas.2306020120. Epub 2023 Oct 2. PubMed PMID: 37782795; PubMed Central PMCID: PMC10576129.

Bamashmous S, Kotsakis GA, Kerns KA, Leroux BG, Zenobia C, Chen D, Trivedi HM, McLean JS, Darveau RP. Human variation in gingival inflammation.
Proc Natl Acad Sci U S A. 2021 Jul 6;118(27). doi: 10.1073/pnas.2012578118. PubMed PMID: 34193520; PubMed Central PMCID: PMC8271746.

Baker J, Mark Welch J, Kauffman K, McLean J, He X. The oral microbiome: diversity, biogeography and human health. Nature Reviews Microbiology. 2023 September; 22(2):89-104. doi: 10.1038/s41579-023-00963-6.

McLean J, Bor B, Kerns K, Liu Q, To T, Solden L, Hendrickson E, Wrighton K, Shi W, He X. Acquisition and Adaptation of Ultra-small Parasitic Reduced Genome Bacteria to Mammalian Hosts. Cell Reports. 2020 July; 32(3):107939-. doi: 10.1016/j.celrep.2020.107939.

Edlund A, Yang Y, Yooseph S, Hall AP, Nguyen DD, Dorrestein PC, Nelson KE, He X, Lux R, Shi W, McLean JS. Meta-omics uncover temporal regulation of pathways across oral microbiome genera during in vitro sugar metabolism. ISME J. 2015 Dec;9(12):2605-19. doi: 10.1038/ismej.2015.72. Epub 2015 May 29. PubMed PMID: 26023872; PubMed Central PMCID: PMC4817640

He X, McLean JS, Edlund A, Yooseph S, Hall AP, Liu SY, Dorrestein PC, Esquenazi E, Hunter RC, Cheng G, Nelson KE, Lux R, Shi W. Cultivation of a human-associated TM7 phylotype reveals a reduced genome and epibiotic parasitic lifestyle. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):244-9. doi: 10.1073/pnas.1419038112. Epub 2014 Dec 22. PubMed PMID: 25535390; PubMed Central PMCID: PMC4291631.