Phage antagonize CRISPR-Cas Immunity
Cryo-EM structure of a phage-encoded anti-CRISPR protein (blue) in complex with the RNA-targeting CRISPR effector Cas13 (gray) and its guide RNA (red).
Credit: Alex Meeske
UW Microbiology Home
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Cell Biology of Bacterial Infection
Listeria monocytogenes (green) interacting with macrophages (red/blue).
Credit: Michelle Reniere
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HIV-1 Envelope Evolution
Reconstructed phylogenetic network of HIV-1 envelope sequences (C2-V5) from subtype B.
Courtesy of: Mullins Lab
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Bacterial Self-Organization
Pseudomonas aeruginosa cells that engage (magenta) or don’t (green) in collective behavior spontaneously self organize in cellular aggregates (3D image acquired by confocal laser scanning microscopy).
Credit: Jeffrey Carey and Matt Parsek
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Emergence of Highly Pathogenic Clones of Escherichia coli
Genetic typing of uropathogeic E. coli reveals strong association of some clones with high sensitivity or extreme resistance to multiple antibiotics.
Courtesy: Sokurenko Lab
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Quorum sensing in Vibrio fischeri
Lux genes coding for light production are activated by quorum sensing at high cell density. The light produced by the bacteria exposed the film for the image.
Courtesy: Greenberg Lab
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Pseudomonas aeruginosa in co-culture
Structural component of bacterial targeting type VI secretion system P. aeruginosa (green) assembled in presence of competitor organism (red).
Courtesy of: Mougous Lab
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Pseudomonas aeruginosa
Colonies of Pseudomonas aeruginosa expressing different amounts of exopolysaccharides.
Courtesy of: Harwood Lab
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YopM Crystal Structure
Crystal structure of the Yersinia virulence protein YopM
Courtesy of: Cookson Lab
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Inflammatory Death of Mouse Macrophages
Mouse macrophages undergoing pyroptosis.
Courtesy of: Cookson Lab
News & Updates
The COVID-19 pandemic brought mRNA vaccines to the forefront and realized, for the first time, their promise of providing a more rapid response to emerging infectious diseases than traditional vaccines. Ideally, vaccines of the future will not only be quick to develop but offer long-term stability at warm temperatures to overcome the barriers of the cold chain for worldwide distribution, achieve a high-level efficacy in the immune-compromised and elderly, induce durable immunity in as few doses as possible and be capable of self-administration.
The Department of Microbiology welcomes new Assistant Professor, Dr. Tristan Jordan, who joined the department in January, 2023.
Dr. Jordan indicates “Several things about the UW and UW Micro drove me to join. First and foremost, was the science. I loved the rigor and diversity of the science that was on-going in the Department of Microbiology and the UW as a whole. The collaborative atmosphere of the Department and biomedical science in Seattle, in general, was also a significant draw. It felt like a breath of fresh air to see and hear about all the collaborations that exists.”
The University of Washington Department of Microbiology has been approved by the Seattle Chapter Achievement Rewards for College Scientists (ARCS) Foundation to receive ARCS funding for Ph.D. candidates starting Autumn quarter 2023. ARCS Foundation’s mission is to support academically outstanding United States citizens studying to complete their degrees in science, medicine and engineering, thereby contributing to the worldwide advancement of
Upcoming Events
Seminar
Orin Smith Auditorium/ Zoom
Speaker:
Dr. Margaret McFall-Ngai
Fast Facts
