With many disease-causing bacteria ratcheting up their shields against current drugs, new tactics are vital to protect people from treatment-resistant infections.
Lowering mutation rates in harmful bacteria might be an as yet untried way to hinder the emergence of antimicrobial-resistant pathogens. This proposed strategy comes from recent findings in infectious disease research at UW Medicine in Seattle.
The University of Washington maintained its No. 10 spot on the U.S. News & World Report’s Best Global Universities rankings, released Tuesday. The UW is second among American public institutions. UW Microbiology is ranked #4!
- Identification of Small Molecule Modulators of Diguanylate Cyclase by FRET-based High-Throughput-Screening.
Chembiochem : a European journal of chemical biology - Nov, 2018
Christen M, Kamischke C, Kulasekara HD, Olivas KC, Kulasekara BR, Christen B, Kline T, Miller SI
- Inhibiting the Evolution of Antibiotic Resistance.
Molecular cell - Nov, 2018
Ragheb MN, Thomason MK, Hsu C, Nugent P, Gage J, Samadpour AN, Kariisa A, Merrikh CN, Miller SI, Sherman DR, Merrikh H
- β-Barrel outer membrane proteins suppress mTORC2 activation and induce autophagic responses.
Science signaling - Nov, 2018
Chaudhary A, Kamischke C, Leite M, Altura MA, Kinman L, Kulasekara H, Blanc MP, Wang G, Terhorst C, Miller SI
- Relational concurrency, stages of infection, and the evolution of HIV set point viral load.
Virus evolution - Jul, 2018
Goodreau SM, Stansfield SE, Murphy JT, Peebles KC, Gottlieb GS, Abernethy NF, Herbeck JT, Mittler JE
- Gene inversion potentiates bacterial evolvability and virulence.
Nature communications - 11, 2018
Merrikh CN, Merrikh H