Sean C. Murphy, MD/PhD
Dr. Murphy's work focuses on human malaria infection. Human and animals can be protected against malaria sporozoites challenge by immunization with attenuated Plasmodium sporozoites. The protective responses induced by these immunizations remain largely unknown because it is extremely difficult to simultaneously monitor responses against hundreds of potential antigens. In collaboration with local and international collaborators, Dr. Murphy studies this complex poly-specific T cell repertoire induced by Plasmodium sporozoites using mouse models of malaria infection and novel high-throughput T cell screening technologies.
A major goal of this work is to identify protective antigens in mice, validate the orthologous antigens in human subjects and develop multi-component subunit vaccines that target the pre-erythrocytic stage of malaria infection. Such vaccines could accelerate the development of effective vaccines for the eradication of malaria. The development of high-throughput tools for T cell antigen discovery would also have broad implications for other infectious and autoimmune diseases and our group is exploring several such possibilities. Dr. Murphy also directs a clinical pathology group devoted to molecular diagnosis of malaria infections. This work supports malaria human challenge trials and allows for detection of malaria parasites in human blood up to 3-4 days earlier than by conventional blood smears.
Recent Publications from PubMed
- Growth Rate of Plasmodium falciparum: Analysis of Parasite Growth Data from Malaria Volunteer Infection Studies.Wockner LF, Hoffmann I, Webb L, Mordmüller B, Murphy SC, Kublin JG, O'Rourke P, McCarthy JS, Marquart LThe Journal of infectious diseases. 2019 Nov; :
- Chemoprophylaxis vaccination: Phase 1 study to explore stage-specific immunity to Plasmodium falciparum in U.S. adults.Healy SA, Murphy SC, Hume JCC, Shelton L, Kuntz S, Van Voorhis WC, Moodie Z, Metch B, Wang R, Silver-Brace T, Fishbaugher M, Kennedy M, Finney OC, Chaturvedi R, Hobbs CV, Warner-Lubin M, Talley AK, Wong-Madden S, Stuart K, Wald A, Kappe SH, Kublin JG, Duffy PEClinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2019 Oct; :
- Murphy SC, Negron ME, Pieracci EG, Deressa A, Bekele W, Regassa F, Wassie BA, Afera B, Hajito KW, Walelign E, Abebe G, Newman S, Rwego IB, Mutonga D, Gulima D, Kebede N, Smith WA, Kramer LM, Kibria A, Bonnenfant YT, Mortenson JA, Vieira AR, Kadzik M, Sugerman D, Amare B, Kanter T, Walke H, Belay E, Gallagher KRevue scientifique et technique (International Office of Epizootics). 2019 May; 38 1: 51-60
- Synthetic osteochondral resurfacing for treatment of large caudocentral osteochondritis dissecans lesions of the humeral head in 24 dogs.Murphy SC, Egan PM, Fitzpatrick NMVeterinary surgery : VS. 2019 Jul; 48 5: 858-868
- Beyond Blood Smears: Qualification of 18S rRNA as a Biomarker for Controlled Human Malaria Infections.Seilie AM, Chang M, Hanron AE, Billman ZP, Stone BC, Zhou K, Olsen TM, Daza G, Ortega J, Cruz KR, Smith N, Healy SA, Neal J, Wallis CK, Shelton L, Mankowski TV, Wong-Madden S, Mikolajczak SA, Vaughan AM, Kappe SHI, Fishbaugher M, Betz W, Kennedy M, Hume JCC, Talley AK, Hoffman SL, Chakravarty S, Sim BKL, Richie TL, Wald A, Plowe CV, Lyke KE, Adams M, Fahle GA, Cowan EP, Duffy PE, Kublin JG, Murphy SCThe American journal of tropical medicine and hygiene. 2019 Jun; 100 6: 1466-1476