James I. Mullins
Dr. Mullins obtained his Ph.D. in Cell Biology and Biochemistry from the University of Minnesota in 1978. He did postdoctoral work at the California Institute of Technology before becoming Assistant then Associate Professor at the Harvard University School of Public Health. In 1989 he moved to Stanford University as Professor and was Chairman of the Department of Microbiology and Immunology from 1991 until his move to the University of Washington in 1994 where he is on the faculty of the Departments of Microbiology, Medicine, and Laboratory Medicine. He served as Chair of Microbiology from 1997-2002. Dr. Mullins has published more than 360 original articles, reviews and book chapters on the topics of retroviruses and AIDS and has delivered more than 320 invited seminars and symposium presentations.
The Mullins lab uses the techniques of molecular, computational and virus biology to provide basic insights into the HIV-human host relationship in an effort to assist the fight to stop the AIDS pandemic. They use a variety of techniques to understand the implications of HIV's extraordinary genetic diversity for the pathogenesis of AIDS, with the intention of applying this information to the development of more effective therapies and vaccines. These techniques include virology, molecular biological and statistical analysis of nucleotide sequences. Additional projects include 2nd generation SARS-CoV-2 vaccine designs and the intra-host diversity of KSHV.
Recent Publications from PubMed
- Control of SARS-CoV-2 infection after Spike DNA or Spike DNA+Protein co-immunization in rhesus macaques.Rosati M, Agarwal M, Hu X, Devasundaram S, Stellas D, Chowdhury B, Bear J, Burns R, Donohue D, Pessaint L, Andersen H, Lewis MG, Terpos E, Dimopoulos MA, Wlodawer A, Mullins JI, Venzon DJ, Pavlakis GN, Felber BKPLoS pathogens. 2021 09; 17 9: e1009701
- Lewitus E, Sanders-Buell E, Bose M, O'Sullivan AM, Poltavee K, Li Y, Bai H, Mdluli T, Donofrio G, Slike B, Zhao H, Wong K, Chen L, Miller S, Lee J, Ahani B, Lepore S, Muhammad S, Grande R, Tran U, Dussupt V, Mendez-Rivera L, Nitayaphan S, Kaewkungwal J, Pitisuttithum P, Rerks-Ngarm S, O'Connell RJ, Janes H, Gilbert PB, Gramzinski R, Vasan S, Robb ML, Michael NL, Krebs SJ, Herbeck JT, Edlefsen PT, Mullins JI, Kim JH, Tovanabutra S, Rolland MVirus evolution. 2021 ; 7 2: veab057
- A Gut Reaction to SIV and SHIV Infection: Lower Dysregulation of Mucosal T Cells during Acute Infection Is Associated with Greater Viral Suppression during cART.O'Connor MA, Munson PV, Dross SE, Tunggal HC, Lewis TB, Osborn J, Peterson CW, Huang MW, Moats C, Smedley J, Jerome KR, Kiem HP, Bagley KC, Mullins JI, Fuller DHViruses. 2021 Aug; 13 8:
- In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia.Cole B, Lambrechts L, Gantner P, Noppe Y, Bonine N, Witkowski W, Chen L, Palmer S, Mullins JI, Chomont N, Pardons M, Vandekerckhove LNature communications. 2021 06; 12 1: 3727
- Corey L, Gilbert PB, Juraska M, Montefiori DC, Morris L, Karuna ST, Edupuganti S, Mgodi NM, deCamp AC, Rudnicki E, Huang Y, Gonzales P, Cabello R, Orrell C, Lama JR, Laher F, Lazarus EM, Sanchez J, Frank I, Hinojosa J, Sobieszczyk ME, Marshall KE, Mukwekwerere PG, Makhema J, Baden LR, Mullins JI, Williamson C, Hural J, McElrath MJ, Bentley C, Takuva S, Gomez Lorenzo MM, Burns DN, Espy N, Randhawa AK, Kochar N, Piwowar-Manning E, Donnell DJ, Sista N, Andrew P, Kublin JG, Gray G, Ledgerwood JE, Mascola JR, Cohen MS,The New England journal of medicine. 2021 03; 384 11: 1003-1014