A short abstract of your topic: The unfolded protein response is a cellular pathway to detect and alleviate dysfunctional protein folding in the endoplasmic reticulum. Our work has characterized multiple mechanisms by which the unfolded protein response component IRE1α contributes to replication of viruses, including hepatitis C virus and Zika virus.
Live Stream this seminar: https://washington.zoom.us/j/564853014
Epstein-Barr virus has the remarkable ability to colonize the B-cell compartment and is also associated with multiple human cancers, including lymphomas of immunosuppressed hosts, Burkitt and Hodgkin lymphoma, nasopharyngeal and gastric carcinomas. To gain insights into how EBV remodels B-cell metabolic pathways to drive and support transformed B-cell growth, we are using temporal proteomic, metabolomic and CRISPR genetic approaches. Together, these are highlighting key metabolic pathways induced upon B-cell infection and vulnerabilities that may ultimately be exploited to target EBV-driven B-cell lymphoproliferative diseases.
Live Stream this seminar: https://washington.zoom.us/j/564853014
