Neutrophils are essential to the innate immune response against invading microorganisms. The ability of neutrophils to kill infectious microorganisms is immediate, non-specific, and not dependent on previous pathogen exposure. A significant component of our research investigates how neutrophils ingest and kill bacteria, and elucidates post-phagocytosis processes important for the resolution of the inflammatory response. A second major focus of our research investigates mechanisms of bacterial pathogenesis. The ultimate goal of our research is to identify novel or improved strategies to control bacterial diseases, including development of diagnostics, vaccines, and therapeutics.