Sean C. Murphy, MD/PhD
Dr. Murphy's work focuses on human malaria infection. Human and animals can be protected against malaria sporozoites challenge by immunization with attenuated Plasmodium sporozoites. The protective responses induced by these immunizations remain largely unknown because it is extremely difficult to simultaneously monitor responses against hundreds of potential antigens. In collaboration with local and international collaborators, Dr. Murphy studies this complex poly-specific T cell repertoire induced by Plasmodium sporozoites using mouse models of malaria infection and novel high-throughput T cell screening technologies.
A major goal of this work is to identify protective antigens in mice, validate the orthologous antigens in human subjects and develop multi-component subunit vaccines that target the pre-erythrocytic stage of malaria infection. Such vaccines could accelerate the development of effective vaccines for the eradication of malaria. The development of high-throughput tools for T cell antigen discovery would also have broad implications for other infectious and autoimmune diseases and our group is exploring several such possibilities. Dr. Murphy also directs a clinical pathology group devoted to molecular diagnosis of malaria infections. This work supports malaria human challenge trials and allows for detection of malaria parasites in human blood up to 3-4 days earlier than by conventional blood smears.
Recent Publications from PubMed
- Exploring Ethical Concerns About Human Challenge Studies: A Qualitative Study of Controlled Human Malaria Infection Study Participants' Motivations and Attitudes.Kraft SA, Duenas DM, Kublin JG, Shipman KJ, Murphy SC, Shah SKJournal of empirical research on human research ethics : JERHRE. 2018 Dec; : 1556264618820219
- Simultaneous Quantification of Antigens and Host Factor C-Reactive Protein in Asymptomatic Individuals with Confirmed Malaria by Use of a Novel Multiplex Immunoassay.Jang IK, Tyler A, Lyman C, Kahn M, Kalnoky M, Rek JC, Arinaitwe E, Adrama H, Murphy M, Imwong M, Ling CL, Proux S, Haohankhunnatham W, Rist M, Seilie AM, Hanron A, Daza G, Chang M, Das S, Barney R, Rashid A, Landier J, Boyle DS, Murphy SC, McCarthy JS, Nosten F, Greenhouse B, Domingo GJJournal of clinical microbiology. 2019 Jan; 57 1:
- Screening for Pfhrp2/3-Deleted Plasmodium falciparum, Non-falciparum, and Low-Density Malaria Infections by a Multiplex Antigen Assay.Plucinski MM, Herman C, Jones S, Dimbu R, Fortes F, Ljolje D, Lucchi N, Murphy SC, Smith NT, Cruz KR, Seilie AM, Halsey ES, Udhayakumar V, Aidoo M, Rogier EThe Journal of infectious diseases. 2019 Jan; 219 3: 437-447
- Olsen TM, Stone BC, Chuenchob V, Murphy SCJournal of immunology (Baltimore, Md. : 1950). 2018 Oct; 201 7: 1984-1993
- Murphy SC, Evans JM, Tsai KL, Clark LAMobile DNA. 2018 ; 9 : 26