Michael Gerald Katze
Dr. Katze is Professor of Microbiology and Associate Director and Core Staff Scientist at the Washington National Primate Research Center. He received his Ph.D. from Hahnemann Medical College and was a postdoctoral fellow at the University of Uppsala in Sweden as part of a fellowship with the European Molecular Biology Organization. Prior to joining the faculty at the University of Washington, Dr. Katze conducted research in molecular biology and virology at the Memorial Sloan-Kettering Cancer Center in New York City.
Research in the Katze lab is focused on the use of systems biology (high-throughput molecular profiling and bioinformatic and computational) approaches to define and model virus-host interactions, innate immune signaling, and the varied strategies used by viruses to evade cellular defense mechanisms. The lab studies a wide range of viral pathogens, including pandemic, seasonal, and highly pathogenic avian influenza viruses, SARS and MERS coronaviruses, Ebola virus, and human and simian immunodeficiency viruses. In addition, the group is spearheading efforts to develop genomic resources for nonhuman primate, ferret, and Syrian hamster models of human virus infection.
The lab has been awarded a $15 million contract to serve as the NIAID Nonhuman Primate Core Functional Genomics Laboratory for AIDS Vaccine Research and Development. This is a national resource for measuring vaccine responses at the molecular level and for discovering markers that may be prognostic in assessing if a vaccine will protect against HIV. In addition, the lab operates Sound Genomics, a fee-for-service next-generation DNA and RNA sequencing facility that specializes in transcriptional profiling and methods for capturing low-abundance host and viral transcripts.
Recent Publications from PubMed
- Ebolaviruses associated with differential pathogenicity induce distinct host responses in human macrophages.Olejnik J, Forero A, Deflubé LR, Hume AJ, Manhart WA, Nishida A, Marzi A, Katze MG, Ebihara H, Rasmussen AL, Mühlberger EJournal of virology. 2017 Mar; :
- A Systems Approach Reveals MAVS Signaling in Myeloid Cells as Critical for Resistance to Ebola Virus in Murine Models of Infection.Dutta M, Robertson SJ, Okumura A, Scott DP, Chang J, Weiss JM, Sturdevant GL, Feldmann F, Haddock E, Chiramel AI, Ponia SS, Dougherty JD, Katze MG, Rasmussen AL, Best SMCell reports. 2017 Jan; 18 3: 816-829
- McDermott JE, Mitchell HD, Gralinski LE, Eisfeld AJ, Josset L, Bankhead A, Neumann G, Tilton SC, Schäfer A, Li C, Fan S, McWeeney S, Baric RS, Katze MG, Waters KMBMC systems biology. 2016 Sep; 10 1: 93
- Wang K, Langevin S, O'Hern CS, Shattuck MD, Ogle S, Forero A, Morrison J, Slayden R, Katze MG, Kirby MPloS one. 2016 ; 11 8: e0160919
- Rasmussen AL, Katze MGCell host & microbe. 2016 May; 19 5: 611-8