HIV, evolution of innate immunity to primate lentiviruses, virus adaptation to new hosts
The Emerman lab studies host-cell interactions of the human immunodeficiency virus (HIV) and related viruses. We wish to understand the molecular and evolutionary basis of virus replication and pathogenesis. We study the evolution and function of host antiviral genes in order to determine how HIV adapted to humans, and how ancient viral infections influenced the susceptibility or resistance of humans to modern lentiviruses.
Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT, Keppler OT
Proceedings of the National Academy of Sciences of the United States of America. 2017 Mar; 114 10: 2729-2734