Mechanistic biology requires both detailed structures, which provide a chemical description of the complex macromolecules that perform the reactions and processes of Life, as well as a means of monitoring and capturing the processes themselves that are dynamic and may not be directly amenable to high-resolution imaging. By combining a suite of techniques including solution X-ray scattering, cryo-EM, fluorescence microscopy, spectroscopy, and solvent exchange methods we aim to integrate observations at all levels of the structural hierarchy. This complementary approach can bring the dynamic processes of the virus life cycle into clearer focus.
Strauch EM, Bernard SM, La D, Bohn AJ, Lee PS, Anderson CE, Nieusma T, Holstein CA, Garcia NK, Hooper KA, Ravichandran R, Nelson JW, Sheffler W, Bloom JD, Lee KK, Ward AB, Yager P, Fuller DH, Wilson IA, Baker D
Joyce MG, Zhang B, Ou L, Chen M, Chuang GY, Druz A, Kong WP, Lai YT, Rundlet EJ, Tsybovsky Y, Yang Y, Georgiev IS, Guttman M, Lees CR, Pancera M, Sastry M, Soto C, Stewart-Jones GB, Thomas PV, Van Galen JG, Baxa U, Lee KK, Mascola JR, Graham BS, Kwong PD