Keith R. Jerome

Contact Information

Email:

kjerome@uw.edu

Phone:

206 667-6793

Office:

Head, Virology Division, Laboratory Medicine

Mail Box:

358080

Keith R. Jerome

Adjunct Professor

Microbiology

Professor

Laboratory Medicine

Current Research:

Dr. Keith R. Jerome holds a B.S. in Chemistry from Georgetown College, and M.D. and Ph.D. degrees from Duke University, where his thesis focused on T cell antigens expressed by breast tumors. He did residency and fellowship training at the University of Washington. Dr. Jerome's research focuses on chronic and latent viruses, their immune evasion mechanisms, and potential curative therapeutic approaches to these infections. His most recent work involves the use of DNA editing enzymes such as homing endonucleases and zinc finger nucleases to specifically target latent viral DNA for cleavage and inactivation. This approach may allow precise elimination of functional viral DNA from infected cell reservoirs, offering the prospect of cure for HIV, hepatitis B, herpes simplex, and human papillomavirus infections.

Recent Publications from PubMed

Human rhinovirus infections in hematopoietic cell transplant recipients: risk score for progression to lower respiratory tract infection.
Waghmare A, Xie H, Kuypers J, Sorror ML, Jerome KR, Englund JA, Boeckh M, Leisenring WM
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2018 Dec; :
RNA sequencing of the i human herpesvirus 6B transcriptome to identify targets for clinical assays distinguishing between latent and active infections.
Hill JA, Ikoma M, Zerr DM, Basom RS, Peddu V, Huang ML, Sedlak RH, Jerome KR, Boeckh M, Barcy S
Journal of virology. 2018 Nov; :
Viral genetics modulate orolabial HSV-1 shedding in humans.
Ramchandani MS, Jing L, Russell RM, Tran T, Laing KJ, Magaret AS, Selke S, Cheng A, Huang ML, Xie H, Strachan E, Greninger AL, Roychoudhury P, Jerome KR, Wald A, Koelle DM
The Journal of infectious diseases. 2018 Nov; :
Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation.
Colonna L, Peterson CW, Schell JB, Carlson JM, Tkachev V, Brown M, Yu A, Reddy S, Obenza WM, Nelson V, Polacino PS, Mack H, Hu SL, Zeleski K, Hoffman M, Olvera J, Furlan SN, Zheng H, Taraseviciute A, Hunt DJ, Betz K, Lane JF, Vogel K, Hotchkiss CE, Moats C, Baldessari A, Murnane RD, English C, Astley CA, Wangari S, Agricola B, Ahrens J, Iwayama N, May A, Stensland L, Huang MW, Jerome KR, Kiem HP, Kean LS
Nature communications. 2018 10; 9 1: 4438
Limited Marginal Utility of Deep Sequencing for HIV Drug Resistance Testing in the Age of Integrase Inhibitors.
Dalmat RR, Makhsous N, Pepper GG, Magaret A, Jerome KR, Wald A, Greninger AL
Journal of clinical microbiology. 2018 Dec; 56 12:

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Profile Last Updated: November 27, 2017

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Contact Information

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Office:

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Keith R. Jerome

Current Research:

Recent Publications from PubMed

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