E. Peter Greenberg
Dr. Greenberg holds a BA in Biology from Western Washington University, a MS in Microbiology from the University of Iowa and a PhD in Microbiology from the University of Massachusetts. After his postdoctoral at Harvard University Dr. Greenberg was on the faculty at Cornell University and then the University of Iowa College of Medicine before moving to the University of Washington in 2005. Dr. Greenberg is an elected member of the National Academy of Sciences, the American Academy of Arts and Sciences, the American Association for the Advancement of Sciences and the American Academy of Microbiology. He is widely credited for founding the quorum sensing field.
The research in Dr. Greenberg’s laboratory is focused on the emerging field of sociomicrobiology. He is principally concerned with three aspects of sociomicrobiology: I. The biochemistry and molecular biology of environmental sensing and response in bacteria with a particular emphasis on a form of chemical communication between bacteria termed quorum sensing. II. The mechanisms by which bacteria switch from a nomadic existence to a sessile biofilm lifestyle and the mechanisms underlying the ability of biofilm bacteria to survive the action of antibiotics. III. The ways in which clonal populations of bacteria can discriminate themselves from other clonal populations. All of these phenomena are of importance in pathogenesis. Dr. Greenberg has concentrated much of his effort on Pseudomonas aeruginosa, an opportunistic pathogenic bacterium that can cause both acute and persistent biofilm infections. Quorum sensing allows certain bacterial species to monitor their own population density and respond by activating transcription of specific sets of genes. Current investigations of gene regulation in Pseudomonas aeruginosa serve as the model for this type of sensing system. The Greenberg lab is studying the binding of the signal to the receptor, the synthesis of the signal, the mechanism of gene activation by this chemical communication system, and the targets of quorum sensing control. Quorum sensing in P. aeruginosa is required for biofilm development and this has led to an effort to understand gene expression in biofilms. The Greenberg lab has identified key regulatory elements that define commitment steps in the development of biofilms and these serve as targets for novel antibiofilm therapeutic development.
Recent Publications from PubMed
- Puri AW, Schaefer AL, Fu Y, Beck DA, Greenberg EP, Lidstrom MEJournal of bacteriology. 2017 Mar; 199 5:
- LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in Pseudomonas aeruginosa.Feltner JB, Wolter DJ, Pope CE, Groleau MC, Smalley NE, Greenberg EP, Mayer-Hamblett N, Burns J, Déziel E, Hoffman LR, Dandekar AAmBio. 2016 Oct; 7 5:
- A LuxR Homolog in a Cottonwood Tree Endophyte That Activates Gene Expression in Response to a Plant Signal or Specific Peptides.Schaefer AL, Oda Y, Coutinho BG, Pelletier DA, Weiburg J, Venturi V, Greenberg EP, Harwood CSmBio. 2016 Aug; 7 4:
- Quorum sensing control of Type VI secretion factors restricts the proliferation of quorum-sensing mutants.Majerczyk C, Schneider E, Greenberg EPeLife. 2016 May; 5 :
- Tseng BS, Majerczyk CD, Passos da Silva D, Chandler JR, Greenberg EP, Parsek MRJournal of bacteriology. 2016 Oct; 198 19: 2643-50