Seminars

Seminar
Tuesday, March 19, 2019   |   through Tuesday, March 19, 2019   |   4pm   |   SLU   |   Speaker: Paul Ahlquist, PhD   |   Host: Dr Jenny Hyde

Positive-strand RNA ((+)RNA) viruses replicate their mRNA-sense genomic RNAs on rearranged host membranes, often in 50 - 100 nm vesicular invaginations, a.k.a. spherules.  Our recent cryo-electron microscopy (cryo-EM) of nodavirus spherules provided the first visualization of viral RNAs and proteins in such complexes.  As predicted by our biochemical results, the membrane spherule is filled with coiled filaments consistent with dsRNA replication templates.  Cytoplasmic filaments, likely representing nascent RNA replication products, emerge from the spherule neck apertures. Each spherule neck is surrounded on the cytoplasmic side of the membrane by a striking 12-fold symmetric proteinaceous ring or “crown” that contains multifunctional nodavirus RNA replication protein A.  Our studies of similar bromovirus RNA replication compartments reveal that virus-induced trans-membrane release of oxidation potential activates late RNA replication functions by disulfide bonding of viral replication factors.  These features provide mechanistic insights into RNA replication compartment structure, assembly, function and control. 

Seminar
Tuesday, April 2, 2019   |   through Tuesday, April 2, 2019   |   4pm   |   HSB T-639   |   Speaker: Dr Ashleigh Theberge   |   Host: Dr Carrie Harwood
Seminar
Tuesday, April 9, 2019   |   through Tuesday, April 9, 2019   |   4pm   |   SLU Orin Smith Auditorium   |   Speaker: Dr Adam Ratner   |   Host: Dr Dave Fredricks
Seminar
Tuesday, April 16, 2019   |   through Tuesday, April 16, 2019   |   4pm   |   HSB T-639   |   Speaker: Dr Grant Jensen
Seminar
Tuesday, April 23, 2019   |   through Tuesday, April 23, 2019   |   4pm   |   SLU Orin Smith Auditorium   |   Speaker: Dr Thirumala-Devi Kanneganti   |   Host: Microbiology Graduate Students
Seminar
Tuesday, April 30, 2019   |   through Tuesday, April 30, 2019   |   4pm   |   HSB T-639   |   Speaker: Dr Stephen Trent   |   Host: Dr Matt Parsek
Seminar
Tuesday, May 7, 2019   |   through Tuesday, May 7, 2019   |   4pm   |   HSB T-639   |   Speaker: Dr Jie Xiao   |   Host: Dr Paul Wiggins
Seminar
Tuesday, May 14, 2019   |   through Tuesday, May 14, 2019   |   4pm   |   HSB T-639   |   Speaker: Dr Maria Hadjifrangiskou   |   Host: Microbiology Senior Fellows
Seminar
Tuesday, May 21, 2019   |   through Tuesday, May 21, 2019   |   4pm   |   HSB T-639   |   Speaker: Dr Shaeri Mukherjee   |   Host: Dr Sam Miller
Seminar
Tuesday, May 28, 2019   |   through Tuesday, May 28, 2019   |   4pm   |   SLU Orin Smith Auditorium   |   Speaker: Dr Sarah Stanley   |   Host: Dr Josh Woodward
Seminar
Tuesday, June 4, 2019   |   through Tuesday, June 4, 2019   |   4pm   |   HSB T-639   |   Speaker: Dr Simon Levin   |   Host: Dr Pete Greenberg